David A. Hood, BPHE, MSc, BA, PhD
Professor, York University
Ingrid Tein, BSc, MD, FRCP
Dr. Tein is Associate Professor of Pediatrics and of Laboratory Medicine and Pathobiology at the University of Toronto and founder and Director of the Neurometabolic Clinic, Investigational Unit and Research Laboratory, Staff Neurologist in the Division of Neurology and Senior Associate Scientist in the Genetics and Genomic Biology Program in the Research Institute at the Toronto Hospital for Sick Children. Dr. Tein directs the Neurometabolic Clinic for the investigation and treatment of children with fatty acid oxidation, mitochondrial, and peroxisomal disorders and cofactor-responsive epilepsies. Her Neuroinvestigational Unit includes prospective cross-over cofactor trials in children with mitochondrial disorders and the ergometric investigation of metabolic myopathies using BOLD-MRI and 31P-MRS spectroscopy. The goal of her Laboratory is the biochemical and molecular investigation of genetic fatty acid oxidation defects and development of in vitro disease models to understand the underlying pathophysiological mechanisms in order to develop new therapies. She has identified novel clinical and biochemical phenotypes and genotypes, developed new diagnostic screening tests, and developed novel treatment strategies aimed at bypassing or correcting the specific metabolic block which have decreased long-term morbidity and mortality in affected children and have been implemented internationally. See More
Mark Tarnopolsky, M.D.
Professor, McMaster University
Neal Sondheimer, MD, PhD
Dr. Neal Sondheimer's research focuses on the regulation of mitochondrial gene expression and the impact of mitochondrial mutations in common and rare disease. Sondheimer is interested in the effects of mitochondrial mutations in common diseases and phenotypes such as Alzheimer disease, aging and preterm birth. Because bioenergetic capacity is critical to many parts of the body, subtle changes in mitochondrial DNA may have profound effects over time.