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Project Leader

Angus McQuibban, PhD
Faculty of Medicine, Department of Biochemistry
Associate Professor
University of Toronto, Ontario
Research Description
After completing his undergraduate degree and M.Sc (Biochemistry) at the University of Toronto, Dr. McQuibban moved to Vancouver to pursue a Ph.D. (Biochemistry and Molecular Biology). His work focused on identifying novel substrates for a class of proteases (MMPs) that contribute to cancer metastasis. He discovered that inflammatory chemokines were a new family of substrates for this enzyme family. After completing his Ph.D. Dr. McQuibban moved to England for PDF at the MRC-Laboratory of Molecular Biology in Cambridge. He continued his work of proteolysis, but this time working with a new family of proteases, called Rhomboids. There Dr. McQuibban revealed their important activity within mitochondria. He started his lab 'back home' in 2005, and since, his research interests have focused on mitochondrial quality control, and how dysregulation leads to human disease. Dr. mcQuibban's lab currently balances basic science projects with translational studies and small molecule screening to develop novel therapeutics in neurodegenerative disease. See More

Network Investigators

Joanne Lemieux, PhD
University of Alberta, Alberta Ontario
Associate Professor and Director of the Membrane Protein Disease Research group
Director, Mitochondrial Bioenergetics Laboratory
Research Description
Joanne Lemieux (PhD, New York University) is an Associate Professor and Director of the Membrane Protein Disease Research group, and leads a multidisciplinary research program focused on membrane protease structure and function. She is internationally recognized as a leader in membrane protein crystallography having solved two distinct membrane protein crystal structures (Science 2003; Proceeding National Academy of Science, 2007). She is an emerging leader in the rhomboid protease field and has developed in vitro assays to determine catalytic parameters of these specialized enzymes (Journal of Molecular biology 2011, EMBOJ 2014).  With their roles in human health and disease, these studies will have direct outcomes to human health and in particular related to our understanding of the role of mitochondrial enzymes in Parkinson's disease.
Thomas Hurd, PhD
Department of Molecular Genetics
Assistant Professor
University of Toronto, Ontario
Research Description
Dr. Hurd's research focuses on studying mitochondrial biology in Drosophila and mammalian systems. In particular, he is interested in determining how mitochondrial DNA is inherited through the female germline (1), and the role mitochondria play in stem cell function, fate and differentiation in vivo (2). Dr. Hurd completed his undergraduate degree at the University of Toronto, his PhD at the University of Cambridge in Mike Murphy's laboratory at the MRC Mitochondrial Biology Unit, and his postdoctoral work with Ruth Lehmann at NYU School of Medicine.
Tim Shutt, PhD
Department of Medical Genetics, Cumming School of Medicine
Assistant Professor
University of Calgary, Alberta
Research Description
Dr. Shutt received his doctorate in Biochemistry and Molecular Biology from Dalhousie University with post-doctoral training at Yale University and the University of Ottawa Heart Institute. His research focuses on understanding basic biological processes required for proper mitochondrial function, namely how mitochondria regulate their dynamic shape and their distinct genome.