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mitoMechanisms

Project Leader

Dr. Yan Burelle, PhD
Department of Cellular and Molecular Medicine
Professor
University of Ottawa, Ottawa, ON
 
Research Description
Dr. Burelle's research program aims to advance the understanding of the complex mechanisms linking mitochondrial biology to health and disease susceptibility. He has received uninterrupted funding from, the Canadian Institutes and Health Research (CIHR) and the Natural Sciences and Engineering Research Council of Canada (NSERC) for more than a decade. He has published more than 60 articles cited more than 6500 times. His laboratory has developed a broad array of methods to assess multiple facets mitochondrial function (respiration, ROS dynamics, Ca2+ regulation, and cell death signalling) in vitro isolated organelles and permeabilized cells, or in situ in intact cells and organs. These approaches have been used not only in basic studies using animal models, but also in tissues from patients in the context of translational research. His laboratory also studies mitochondrial quality control mechanisms both in vitro with biochemical and confocal imaging approaches, and in vivo  with quantitative electron microscopy and mitophagy reporter proteins. Overall, this enables his laboratory to tackle several questions related to mitochondria at multiple levels of biological complexity.
Iveta Sosova, PhD
Biochemical Geneticist
 
Assistant Professor, Dept. of Laboratory Medicine and Pathology, University of Alberta
Joint Laboratory Head, Newborn Metabolic Screening and Biochemical Genetics Laboratory, University of Alberta Hospital, Edmonton, Alberta
 
Research Description
Dr. Sosova received a PhD in Biochemical Sciences from the National Autonomous National University of Mexico (UNAM) in Mexico City. During her postdoctoral research at Queen's University in Kingston, ON and University of Alberta in Edmonto, AB, she studied the cytochorme c oxidase assembly process and also worked on development of a microfluidic method for molecular analysis of mitochondrial DNA.
 
Her primary research interest focuses on the understanding of the functional role of the mitochondrial oxidative phosphorylation (OXPHOS) supercomplexes. As a fellow of the Canadian College of Medical Geneticists at the University of Calgary, she worked on the development of a diagnostic tool for the interrogation of novel forms of infantile mitochondrial disease. She developed a hybrid method combining both blye native- and clear native polyacrylamide gel electrophoresis techniques, termed BCN-PAGE, to assess the structural organization, assembly and stability of the OXPHOS (super/supra) complexes in skin fibroblasts. Defects in proper assembly of these supercomplexes have been associated with many mitochondrial disorders.
Ana Andreazza, PhD
Associate Professor, University of Toronto
Department of Pharmacology and Toxicology
Department of Psychiatry
Collaborator Scientist, Centre for Addiction and Mental Health (CAMH)
Tier II Canada Research Chair in Molecular Pharmacology of Mood Disorders
 
Research Description
Dr. Andreazza has published over 140 research articles with an h-index of 42. She is the recipient of several prestigious awards and has received funding from the Brain and Behaviour Foundation (NARSAD), the Canadian Institutes for Health Research, the Ontario Mental Health Foundation and the Ontario Ministry of Research and Innovation . Her research focuses on the understanding of the role of redox modulations and mitochondrial dysfunction in mental illness, especially in mood disorders. Dr. Andreazza's current research focus is on the brain and its redox biology, with particular reference to the role of mitochondrial dysfunction and the impact of redox modification on the inflammatory system and illness progression in major psychiatric disorders and mitochondrial diseases, with the objective of identifying biological targets that will open doors to the development of new treatment strategies.